Traditional Chinese Medicine and Its Effective Components in Treating Alzheimer's Disease： A Review
10.13422/j.cnki.syfjx.20232437
- VernacularTitle:中药及其有效成分治疗阿尔茨海默病研究进展
- Author:
Shan CAO
1
;
Zhihui CHEN
1
;
Jingqi QIN
1
;
Huiyong ZHANG
2
;
Li YU
2
;
Wei WU
3
Author Information
1. Liaoning University of Traditional Chinese Medicine， Shenyang 110847， China
2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine， Shenyang 110032， China
3. Zhuhai College of Science and Technology， Zhuhai 519041， China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
traditional Chinese medicine;
mechanism of action;
ferroptosis;
gut-brain axis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(10):258-268
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease is a common central neurodegenerative disease， mainly manifested by cognitive impairment and non-cognitive neuropsychiatric symptoms that severely affect patients' daily life and behavioral functioning. The pathogenesis of Alzheimer's disease is still unclear， and the western medicine currently used to treat Alzheimer's disease is only symptomatic， with a single pathway， limited efficacy， and many side effects. In recent years， with the deepening of research on Alzheimer's disease， the study and application of traditional Chinese medicine （TCM） in the treatment of Alzheimer's disease have gradually increased. Several studies have shown that TCM and its effective components can exert anti-Alzheimer's disease effects by regulating molecular mechanisms such as pathological protein production and aggregation， oxidative stress， neuroinflammation， ferroptosis， mitochondrial dysfunction， neurogenesis and neurotransmission， and brain-gut axis. This paper summarized the research progress of TCM in the treatment of Alzheimer's disease in recent years， so as to provide a reference for further study of the specific mechanism of TCM in the prevention and treatment of Alzheimer's disease and the discovery of effective components of TCM.
