Biological Basis of Premature Ejaculation Based on Theory of "Brain-heart-kidney-semen Chamber" Axis
10.13422/j.cnki.syfjx.20241393
- VernacularTitle:基于“脑-心-肾-精室”轴理论探讨早泄的生物学基础
- Author:
Dongyue MA
1
;
Anmin WANG
1
;
Jiutian YANG
1
;
Dicheng LUO
1
;
Ziwei ZHAO
1
;
Jun GUO
1
;
Fu WANG
1
Author Information
1. Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
premature ejaculation;
"brain-heart-kidney-semen chamber" axis;
5-hydroxytryptamine;
neurotransmitters;
biological basis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(10):203-209
- CountryChina
- Language:Chinese
-
Abstract:
The theory of "brain-heart-kidney-semen chamber" axis is proposed based on the basic theories of traditional Chinese medicine， the modern physiological characteristics of men's diseases， and clinical practice. According to this theory， dysfunctions of the brain， heart， kidney， and semen chamber are the core mechanisms for the occurrence of premature ejaculation， and the loss of control of the opening and closing of the seminal orifices due to the dysfunction of the semen chamber is the final link in the occurrence of premature ejaculation. The treatment of premature ejaculation based on the theory of "brain-heart-kidney-essence chamber" axis highlights the overall regulation of the Zang-fu organs involved in the disease， while focusing on the simultaneous treatment of the mind and body. By exploring the biological basis of the "brain-heart-kidney-essence chamber" axis and premature ejaculation， we propose that the biological basis of premature ejaculation and the axis is mainly related to the function decline of the local brain area， neuromodulation malfunction， central neurotransmitter imbalance， endocrine disorders， and enhanced sensory afferents of the penis. This study aims at providing a new approach for the prevention and treatment of premature ejaculation by traditional Chinese medicine and a scientific basis for the development of more effective therapeutic methods.
