Low BMI is Associated with Poor OI-IUI Outcomes in Patients with Unexplained Primary Infertility
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240305.003
- VernacularTitle:低体质指数不利于不明原因原发不孕患者人工授精诱导排卵周期妊娠结局
- Author:
Yihua LIANG
1
;
Xuedan JIAO
1
;
Qingxue ZHANG
1
;
Hui CHEN
1
;
Yu LI
1
Author Information
1. Reproductive Center， Sun Yat-sen Memorial Hospital， Sun Yat-sen University//Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases， Guangzhou 510020， China
- Publication Type:Journal Article
- Keywords:
unexplained infertility;
body mass index;
intrauterine insemination;
live birth;
clinical outcomes
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(2):283-289
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect of women's body mass index （BMI） on pregnancy outcomes of ovulation induction intrauterine insemination （OI-IUI） in patients with unexplained primary infertility. MethodsThe study included 764 OI-IUI cycles from January 2016 to December 2022 in reproductive center of Sun Yat-sen Memorial Hospital. According to BMI，patients were divided into three groups：low BMI （BMI<18.5 kg/m2）， normal BMI （18.5 kg/m2 ≤BMI＜23.0 kg/m2）， and high BMI （BMI≥23.0 kg/m2）. Comparison of clinical data and pregnancy outcomes was performed between the groups. Logistic regression was used to analyze the association between BMI and live birth rate. ResultsFrom the low BMI group to the high BMI group， the HCG positive rate （7.08%，9.74%， 13.19%）， clinical pregnancy rate（5.51%， 7.91%， 13.19%）， and live birth rate （4.72%， 6.90%， 12.50%） increased. Among them， the live birth rate of the high BMI group was significantly higher than that of the low BMI group and the normal BMI group， with a statistically significant difference （P=0.034）. While the early miscarriage rate （14.28%， 10.26%， 5.26%） decreased from the low BMI group to the high BMI group. The binary logistic regression analysis revealed that BMI was an independent factor in live birth， and high BMI resulted in a better live birth rate than low BMI （OR=3.15，95%CI=1.191-8.329，P=0.021）. ConclusionLow BMI is associated with poor OI-IUI outcomes in patients with unexplained primary infertility. These patients are encouraged to gain weight in a healthy manner.
