Viral pathogen spectrum analysis of acute intestinal infection in Hanzhong in 2019-2022
10.3969/j.issn.1006-2483.2024.02.013
- VernacularTitle:2019—2022年陕西汉中地区急性肠道感染病毒病原谱分析
- Author:
Weijie NIE
1
;
Wei WANG
1
;
Liqin HE
1
Author Information
1. Department of Gastroenterology , 3201 Hospital Hanzhong , Hanzhong , Shaanxi 723000 , China
- Publication Type:Journal Article
- Keywords:
Acute intestinal infection;
Enterovirus;
Pathogen spectrum;
Epidemiology
- From:
Journal of Public Health and Preventive Medicine
2024;35(2):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the viral pathogen spectrum characteristics of acute intestinal infection in Hanzhong from 2019 to 2022. Methods Fecal samples from patients with acute intestinal infection in the outpatient clinic of 3201 Hospital from January 2019 to December 2022 were collected. Common enteroviruses such as enterovirus 71 (EV-A71), coxsackievirus 16 (CV-A16), CV-A10, CV-A6, CV-A2, CV-A4, and CV-B3 were detected and analyzed by real-time fluorescence quantitative PCR. Results A total of 5 194 fecal samples were collected, and the positive rate of nucleic acid detection was 23.95%. In terms of the enteroviruses, the highest detection rate was 9.82% for EV-A71, followed by 4.58% for CV-A16 and 3.37% for CV-A6. The positive detection rate of common enteroviruses showed statistical difference among different age groups (P<0.05), with the highest detection rate of 41.49% in 0-4 years old group. There was no significant difference in the positive virus detection rate between different genders (P>0.05). EV-A71 infection showed no seasonal characteristics, whereas the detection of CV-A16 and CV-A6 infections was concentrated in summer and autumn. There were 106 cases of mixed infection, and the prevalence rate was 2.04%, with EV-A71 and CV-A6 mixed infections accounting for the majority of cases. Conclusion The main pathogens of acute intestinal infections in the Hanzhong area from 2019 to 2022 are EV-A71, CV-A16, and CV-A6. It is necessary to strengthen the monitoring of acute intestinal infections in children aged 4 years and below.
