Application of Circulating Tumor DNA in Precision Diagnosis and Treatment of Colorectal Cancer
10.3971/j.issn.1000-8578.2024.23.1237
- VernacularTitle:循环肿瘤DNA在结直肠癌精准诊疗中的应用
- Author:
Wentao YANG
1
,
2
;
Minghan LI
;
Jidong CAI
;
Cong LI
;
Wang SONG
;
Ye XU
Author Information
1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center
2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
Colorectal cancer;
Circulating tumor DNA;
Precise treatment;
Screening;
Treatment efficacy evaluation;
Drug resistance;
Tumor recurrence;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2024;51(3):157-162
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer (CRC) is one of the most common malignant tumors recorded worldwide. This condition has high morbidity and mortality and seriously endangers people's health. Traditional diagnostic models fail to meet people's current needs for real-time monitoring of tumors. Compared with traditional detection methods, ctDNA detection is not only noninvasive but can also attain real-time detection of comprehensive genomic information of tumors. The advancement of detection technology has gradually highlighted the potential of ctDNA detection in the clinical treatment of CRC. This article reviews the advancements on the clinical application of ctDNA in early screening, minimal residual disease detection, and guidance on individualized treatment of CRC patients.
