Progress in Research on Influence of Autoantibodies on Biochemical Response and Prognosis in Patients With Primary Biliary Cholangitis
10.3969/j.issn.1008-7125.2020.07.014
- Author:
Guifang HUANG
1
;
Jinhui YANG
1
;
Yingmei TANG
1
;
Wenlin TAI
1
;
Ting JIANG
1
;
Yueshan YIN
1
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Autoantibodies;
Biochemical Response;
Primary Biliary Cholangitis;
Prognosis
- From:Chinese Journal of Gastroenterology
2020;25(7):445-448
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease, and may progress to cirrhosis and associated with complications of end-stage liver disease. The immunological characteristic of PBC is the presence of anti-mitochondrial autoantibodies (AMAs), and some anti-nuclear antibodies (ANAs) have high specificity for the diagnosis of PBC. In recent years, it has been found that anti-gp210, anti-sp100 and anti-centromere antibodies are correlated with the severity of PBC, treatment response to ursodeoxycholic acid (UDCA) and poor prognosis. However, correlation between AMAs and disease progression of PBC is still in controversial. This article reviewed the progress in research on the influence of autoantibodies on biochemical response and prognosis of PBC.
