Progress in Research on Mechanosensitive Ion Channel Piezo1/2 in Digestive System Diseases
10.3969/j.issn.1008-7125.2020.09.009
- Author:
Caiyuan LIU
1
;
Jun SONG
1
;
Xiaohua HOU
1
Author Information
1. Division of Gastroenterology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Digestive System Diseases;
Mechanosensitive Ion Channels;
Piezo1/2;
Therapy
- From:
Chinese Journal of Gastroenterology
2020;25(9):560-563
- CountryChina
- Language:Chinese
-
Abstract:
Piezo proteins, including Piezo1, Piezo2, are non-selective mechanosensitive ion channels. They have similar biophysical characteristics, which can transform mechanical signals into biological electric signals. Studies have shown that Piezo proteins play important roles in mechanical-relevant physiological functions and pathophysiological changes of a variety of organs, including gastrointestinal tract. This article reviewed the relationship between Piezo1/2 proteins and digestive system diseases, and discussed the roles of Piezo1/2 under mechanical stress in the development of digestive system diseases, so as to provide a novel target in the study of pathogenesis and treatment of relevant digestive system diseases.
