Bile Acid Receptors in Gastrointestinal Inflammation and Tumorigenesis
10.3969/j.issn.1008-7125.2020.09.008
- Author:
Jingxian XU
1
;
Lungen LU
1
;
Hui ZHOU
1
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Bile Acids;
Farnesoid X Receptor;
G-Protein-Coupled Receptor 5;
Inflammation;
Neoplasms
- From:
Chinese Journal of Gastroenterology
2020;25(9):556-559
- CountryChina
- Language:Chinese
-
Abstract:
Addition to fat digestion and absorption, bile acids also act as signaling molecules through activating bile acid receptors. Increasing evidences have shown that bile acid receptors are closely related to the occurrence of gastrointestinal diseases. TGR5 and FXR play important roles in bile acid metabolism, regulation of glucose utilization, control of energy homeostasis and regulation of immune cell function. Both FXR and TGR5 inhibit gastrointestinal inflammation, however, the former negatively regulates intestinal tumorigenesis, while the latter may be positively related with gastrointestinal tumors. This article reviewed the immune regulatory effects of TGR5 and FXR on gastrointestinal tract.
