Advances in Research on Lactobacillus rhamnosus GG in Colorectal Cancer
10.3969/j.issn.1008-7125.2020.10.010
- Author:
Yujiao WU
1
;
Wei ZHANG
1
Author Information
1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University
- Publication Type:Journal Article
- Keywords:
Colorectal Neoplasms;
Lactobacillus rhamnosus GG;
Prevention;
Therapy
- From:
Chinese Journal of Gastroenterology
2020;25(10):623-627
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a kind of malignant tumor that occurs in colorectal mucosal epithelium. Its morbidity and mortality are of the leading rank in the world. Probiotics are active microorganisms beneficial to the host, which can reduce the risk of malignant tumor by competing with pathogens, destroying potential carcinogens, reducing microbial genotoxicity, enhancing intestinal barrier and host innate immunity, regulating cell proliferation and apoptosis and other mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the earliest and most widely studied probiotics, which has shown great potential in the tertiary prevention of cancer by regulating intestinal flora, anti-inflammatory, anti-proliferative and pro-apoptotic mechanisms. This article reviewed the advances in research on LGG in colorectal cancer.
