Advances in Study on Role of Neutrophil Infiltration in Helicobacter pylori Infection-related Diseases
10.3969/j.issn.1008-7125.2020.11.012
- Author:
Xiaobei SI
1
;
Shigang DING
1
;
Yanyan SHI
2
;
Xiaobei SI
3
Author Information
1. Department of Gastroenterology, Peking University Third Hospital
2. Research Center of Clinical Epidemiology, Peking University Third Hospital
3. Department of Gastroenterology, Beijing Jishuitan Hospital
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Inflammation;
Neutrophil Infiltration
- From:
Chinese Journal of Gastroenterology
2020;25(11):696-699
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) is a microaerophilic Gram-negative bacterium that colonizes the gastric mucosa. After colonization, many proteins expressed by Hp, such as Helicobacter pylori urease (HPU), neutrophil-activating protein (NAP), outer membrane protein (OMP), cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), may serve as antigens to mediate neutrophil chemotaxis. Thereafter, neutrophils infiltrate in gastric mucosa and play roles in mucosal immunity via secreting cytokines and releasing reactive oxygen species (ROS) and myeloperoxidase (MPO). This article reviewed the advances in study on the role of neutrophil infiltration in Hp infection-related diseases.
