Intestinal Mucus Barrier: From Basic Research to Clinical Practice
10.3969/j.issn.1008-7125.2020.11.009
- Author:
Yilin XIONG
1
;
Jun SONG
1
;
Xiaohua HOU
1
Author Information
1. Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Extraintestinal Diseases;
Goblet Cells;
Intestinal Diseases;
Mucins;
Mucus Barrier
- From:
Chinese Journal of Gastroenterology
2020;25(11):682-686
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal mucus barrier is a gel network composed of mucin, water and antimicrobial peptides. It is the first line defense of host against intestinal pathogens, and is also important for the survival and proliferation of symbiotic bacteria. Mucins are mainly synthesized and secreted by goblet cells of intestine, forming different structures in different intestinal segments. Nowadays more and more studies have shown that the mucus barrier is not only closely related to intestinal infection, inflammatory bowel disease, intestinal tumor and other intestinal diseases, but also involved in the occurrence and development of some extraintestinal diseases, such as acute pancreatitis, non-alcoholic fatty liver disease, which may become a new target for the treatment of various related diseases in the future.
