Research Status of Exosomes and Pathogenesis of Inflammatory Bowel Disease

Author: Xiangdian BU ¹ ; Baoyue LI ¹ ; Wenxuan CHEN ¹ ; Dandan WANG ¹ ; Yaxing SUN ¹ ; Baisui FENG ¹
Author Information

1. Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University
Publication Type:Journal Article
Keywords: Cytokines; Exosomes; Immune Regulation; Inflammatory Bowel Disease
From:Chinese Journal of Gastroenterology 2020;25(12):749-753
CountryChina
Language:Chinese
Abstract: Exosomes are extracellular vesicles with a diameter of 30-150 nm, which exist in multi-vesicular bodies in the form of intraluminal vesicles. Exosomes can be secreted by a variety of immune cells. Studies have shown that exosomes might play an important role in IBD through their components, such as annexin-A1 (ANXA1), the miRNAs and lipids. As a carrier of antigen presentation, it can affect the signaling pathways related to IBD, regulate the immune response and intestinal homeostasis. This article reviewed the relationship between exosomes and IBD.