Advances in Studies on Short-chain Fatty Acids in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2021.01.009
- Author:
Ziyun GAO
1
;
Zhenhua WANG
1
Author Information
1. Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Publication Type:Journal Article
- Keywords:
Immunomodulation;
Inflammatory Bowel Disease;
Intestinal Microbiota;
Short-Chain Fatty Acids
- From:
Chinese Journal of Gastroenterology
2021;26(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic inflammatory disease driven by genetic and environmental factors. Short-chain fatty acids (SCFAs), which are produced by fermentation of dietary fiber by intestinal microbiota, have anti-inflammatory effect and are involved in the maintenance of intestinal homeostasis. Intestinal inflammation and low fiber diet can reduce the number of SCFAs-producing bacteria and thereby affecting intestinal immune and metabolic regulation. This article reviewed the advances in studies on SCFAs in IBD.
