Analysis of Clinical Factors of Ulcerative Colitis Complicated With Anemia
10.3969/j.issn.1008-7125.2021.03.006
- Author:
Wenxuan CHEN
1
;
Baoyue LI
1
;
Xiangdian BU
1
;
Na MA
1
;
Zhe ZHANG
1
;
Baisui FENG
1
Author Information
1. Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Anemia;
C-Reactive Protein;
Colitis, Ulcerative;
Erythrocyte Sedimentation Rate;
Erythrocytes;
Hemoglobin
- From:
Chinese Journal of Gastroenterology
2021;26(3):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Background: The prevalence of inflammatory bowel disease (IBD) is increasing worldwide, and anemia, one of the most prevalent extraintestinal manifestations of IBD, is still often underdiagnosed and undertreated. Aims: To analyze the correlations of clinical factors with anemia in patients with ulcerative colitis (UC). Methods: A retrospective analysis was conducted in 60 cases of UC admitted from September 2019 to May 2020 at the Second Affiliated Hospital of Zhengzhou University. Sixty healthy subjects were served as controls. Data of fasting venous blood sample analysis on admission were collected, and the correlations of indicators for anemia with the clinical factors were analyzed. Results: The indicators for anemia, including red blood cell (RBC) count, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) etc. were significantly decreased in UC patients than in healthy controls (all P<0.05). RBC was lower in females than in males (P<0.05); RBC and HCT were lower in patients with pancolitis than in those with proctitis or left hemi-colon colitis (all P<0.05); RBC, Hb and HCT were lower in severe active UC than in mild active UC (all P<0.05). RBC, Hb, HCT and MCH were negatively correlated with two disease activity indicators for IBD, C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR) (all P<0.05). Conclusions: Gender, as well as the disease extent, activity and severity are important clinical factors for anemia in patients with UC.
