Advance in Study on tRNA-derived Small Non-coding RNAs in Gastrointestinal Tumors
10.3969/j.issn.1008-7125.2021.04.008
- Author:
Sihua LAN
1
;
Junchi QU
1
;
Shineng ZHANG
1
Author Information
1. Department of Gastroenterology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Digestive System Neoplasms;
Small Non-Coding RNA;
Transfer RNA
- From:
Chinese Journal of Gastroenterology
2021;26(4):235-239
- CountryChina
- Language:Chinese
-
Abstract:
Transfer RNA (tRNA)-derived small non-coding RNAs (tsRNAs) are generated through specific endonucleolytic cleavage of mature or precursor tRNA at different sites and exist widely in prokaryotic and eukaryotic transcriptome, and are a new class of gene expression regulators with a variety of biological functions. tsRNAs participate in some physiological and pathological processes, including stress response, protein translation, ribosomal biosynthesis and regulating immunity. Dysregulation of tsRNAs is closely related with the occurrence and development of many human diseases. This article reviewed the advance in study on tsRNAs in gastrointestinal tumors.
