Digestive Manifestations and Pathogenesis in Patients With COVID-19
10.3969/j.issn.1008-7125.2021.04.007
- Author:
Guoyu GUAN
1
;
Songbai ZHENG
1
;
Min CHEN
2
Author Information
1. Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University
2. Department of Geriatrics, Zhongnan Hospital of Wuhan University
- Publication Type:Journal Article
- Keywords:
Angiotensin Converting Enzyme 2;
COVID-19;
Digestive System
- From:
Chinese Journal of Gastroenterology
2021;26(4):231-234
- CountryChina
- Language:Chinese
-
Abstract:
COVID-19 currently is a major pandemic disease in the world. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the β-coronavirus genus that has 79% homology with severe acute respiratory syndrome (SARS) virus and can lead to acute respiratory infection. While COVID-19 patients typically present with respiratory symptoms such as fever, cough, some patients also report symptoms of digestive system. Studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients, and the viral receptor angiotensin converting enzyme 2 (ACE2) is found to be expressed in gastrointestinal epithelial cells, hepatic cells and pancreatic cells, suggesting that fecal-mouth route is a potential route for transmission of SARS-CoV-2. This article reviewed the digestive manifestations and pathogenesis of patients with COVID-19.
