Role of Stress Response Caused by Helicobacter pylori Infection in Gastric Mucosal Diseases
10.3969/j.issn.1008-7125.2021.08.012
- Author:
Dongxue ZHANG
1
;
Yanyan SHI
1
;
Shigang DING
1
Author Information
1. Department of Gastroenterology, Peking University Third Hospital, Research Center of Clinical Epidemiology, Peking University Third Hospital
- Publication Type:Journal Article
- Keywords:
Endoplasmic Reticulum Stress;
Gastric Mucosal Diseases;
Helicobacter pylori;
Nitrosative Stress;
Oxidative Stress
- From:
Chinese Journal of Gastroenterology
2021;26(8):503-506
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) is a Gram-negative bacterium selectively colonized in gastric mucosa, and is one of the main factors inducing chronic gastritis and even gastric cancer. Recent studies have shown that Hp infection induces various stress responses, including oxidative stress, nitrosative stress and endoplasmic reticulum stress. Hp can stimulate neutrophils, macrophages and gastric epithelial cells to express reactive oxygen species and reactive nitrogen species, resulting in excessive accumulation of reactive oxygen species and reactive nitrogen species, aggravating inflammation and damage to gastric mucosa. Such long-term inflammation and oxidative stress may increase the risk of cancer. In addition, Hp induced endoplasmic reticulum stress plays an important role in the early stages of precancerous lesion formation. This article reviewed the research progress of role of stress response induced by Hp infection in gastric mucosal diseases.
