Research of Glial Cell Line-derived Neurotrophic Factor in Gastrointestinal Diseases
10.3969/j.issn.1008-7125.2021.08.011
- Author:
Xiaodan ZHANG
1
;
Ying XU
1
;
Guogang LIANG
1
Author Information
1. Department of Emergency Abdominal Surgery, The First Affiliated Hospital of Dalian Medical University & Institute (College) of Integrative Medicine
- Publication Type:Journal Article
- Keywords:
Enteric Glial Cells;
Gastrointestinal Diseases;
Glial Cell Line-Derived Neurotrophic Factor
- From:
Chinese Journal of Gastroenterology
2021;26(8):498-502
- CountryChina
- Language:Chinese
-
Abstract:
Glial cell line-derived neurotrophic factor (GDNF) is an important functional protein derived from enteric glial cells. It plays an important role in the enteric nervous system, such as nutritional neurons, promoting synaptic remodeling and anti-inflammation. The role of GDNF in the progression of gastrointestinal diseases has received more attention gradually. This article reviewed GDNF and its ligands, related signaling pathway, correlation with intestinal homeostasis and clinical application.
