Expressions and Significance of Livin, Survivin, Pak-1 and Caspase-7 in Different Gastric Mucosal Lesions
10.3969/j.issn.1008-7125.2021.08.007
- Author:
Shuyu JIANG
1
;
Limei REN
2
;
Jinbao WU
2
;
Jiaxin LOU
2
;
Qihao SU
2
;
Xiaofang LIU
2
Author Information
1. Baotou Medical College, Inner Mongolia University of Science and Technology
2. Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College
- Publication Type:Journal Article
- Keywords:
Caspase-7;
Immunohistochemistry;
Livin;
Pak-1;
Stomach Neoplasms;
Survivin
- From:
Chinese Journal of Gastroenterology
2021;26(8):481-485
- CountryChina
- Language:Chinese
-
Abstract:
Background: Livin, survivin and Pak-1 are all related to the occurrence and development of gastric cancer. Livin and survivin play their roles by inhibiting the activity of caspase-7. Aims: To investigate the expressions and significance of livin, survivin, Pak-1 and caspase-7 in different gastric mucosal lesions. Methods: A total of 45 cases of gastric cancer and paracancerous tissue, 45 chronic atrophic gastritis with intestinal metaplasia, 45 chronic non-atrophic gastritis from Jan. 2015 to Dec. 2019 at the Second Affiliated Hospital of Baotou Medical College were collected. Immunohistochemistry was used to detect the expressions of livin, survivin, Pak-1 and caspase-7, and their correlations with clinicopathological features of gastric cancer patients were analyzed. Results: Compared with chronic non-atrophic gastritis group and paracancerous group, the positivity expression rates of livin, survivin and Pak-1 in intestinal metaplasia group were significantly increased (P<0.05), while caspase-7 was significantly decreased (P<0.05). Compared with intestinal metaplasia group, the positivity expression rates of livin, survivin and Pak-1 in gastric cancer group were significantly increased (P<0.05), while caspase-7 was significantly decreased (P<0.05). Expressions of livin, survivin, Pak-1 and caspase-7 were correlated with the differentiation degree, TNM stage, depth of infiltration and lymph node metastasis in patients with gastric cancer (P<0.05). Conclusions: Livin, survivin, Pak-1 and caspase-7 play important roles in the occurrence and development of gastric cancer.
