Expression and Clin ical Significance of B7-H5 in Ulcerative Colitis

Lu Xia; Yanjun Chen; Yuqi Chen; Juntao LI; Jiayu Wang; Linqing Sun; Jinghan Zhu; Tongguo Shi; Qinhua XI; Rui LI; Lu Xia; Yanjun Chen; Yuqi Chen; Juntao LI; Jiayu Wang; Linqing Sun; Jinghan Zhu; Tongguo Shi; Rui LI; Lu Xia; Yanjun Chen; Yuqi Chen; Juntao LI; Jiayu Wang; Linqing Sun; Jinghan Zhu; Tongguo Shi; Rui LI; Lu Xia; Yanjun Chen; Yuqi Chen; Juntao LI; Jiayu Wang; Linqing Sun; Jinghan Zhu; Tongguo Shi; Rui LI

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Expression and Clin ical Significance of B7-H5 in Ulcerative Colitis

Author: Lu XIA ¹ ; Yanjun CHEN ¹ ; Yuqi CHEN ¹ ; Juntao LI ¹ ; Jiayu WANG ¹ ; Linqing SUN ¹ ; Jinghan ZHU ¹ ; Tongguo SHI ¹ ; Qinhua XI ¹ ; Rui LI ¹ ; Lu XIA ² ; Yanjun CHEN ² ; Yuqi CHEN ² ; Juntao LI ² ; Jiayu WANG ² ; Linqing SUN ² ; Jinghan ZHU ² ; Tongguo SHI ² ; Rui LI ² ; Lu XIA ³ ; Yanjun CHEN ³ ; Yuqi CHEN ³ ; Juntao LI ³ ; Jiayu WANG ³ ; Linqing SUN ³ ; Jinghan ZHU ³ ; Tongguo SHI ³ ; Rui LI ³ ; Lu XIA ⁴ ; Yanjun CHEN ⁴ ; Yuqi CHEN ⁴ ; Juntao LI ⁴ ; Jiayu WANG ⁴ ; Linqing SUN ⁴ ; Jinghan ZHU ⁴ ; Tongguo SHI ⁴ ; Rui LI ⁴
Author Information

1. Department of Gastroenterology, The First Affiliated Hospital of Soochow University
2. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University
3. Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology
4. Suzhou Key Laboratory for Tumor Immunology of Digestive Tract
Publication Type:Journal Article
Keywords: B7-H5; Colitis; Immunofluorescence; Immunohistoehemistry; Negative Costimulatory Molecules; Ulcerative
From: Chinese Journal of Gastroenterology 2022;27(1):21-25
CountryChina
Language:Chinese
Abstract: Background: The incidence of ulcerative colitis (UC) has gradually increased in China in recent years. The pathogenesis of UC is related to the dysfunction of immune system. B7-H5 is an important immune checkpoint molecule and is significant for the regulation of immune function. Ainis: To investigate the expression and clinical significance of B7-H5 in UC. Methods: A total of 65 UC tissue specimens were collected from Jan. 2010 to Dec. 2020 at the First Affiliated Hospital of Soochow University, and 5 healthy subjects were served as controls. Immunohistoehemistry and immunofluorescence were used to detect the expression of B7-H5, and its relationship with elinieopathologieal characteristics of UC patients was analyzed. Results: Expression of B7-H5 was significantly increased in UC patients than in controls (P < 0. 001). B7-H5 expression in UC patients was positively correlated with ESR and CRP (P < 0. 01), but not related to gender, age, extent of lesion, Mayo score and UCEIS score (P > 0. 05). Conclusions; The expression of B7-H5 in UC patients is significantly increased and is correlated with ESR and CRP, and can be used as a new marker for reflecting the severity of inflammation in UC patients.