Analysis of Risk Factors of Drug Resistance in Patients With Helicobacter pylori Infection
10.3969/j.issn.1008-7125.2022.02.005
- Author:
Hao MEI
1
;
Zhe ZHAO
1
;
Jingtao ZHAO
1
;
Nayun SU
1
;
Qing SHI
1
;
Jie HU
1
;
Jing YANG
1
;
Yangjie ZHU
1
;
Chunhui LAN
1
Author Information
1. Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University, Third Military Medical University
- Publication Type:Journal Article
- Keywords:
Anti‑Bacterial Agents;
Drug Resistance;
Helicobacter pylori;
Risk Factors
- From:Chinese Journal of Gastroenterology
2022;27(2):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Background: The increasing in antibiotic resistance of Helicobacter pylori (Hp) has become the main cause leading to the decreasing of the eradication rate for Hp treatment. Aims: To investigate the risk factors of drug resistance of Hp. Methods: Data on 396 patients with Hp infection from Dec. 2016 to Mar. 2021 at Army Medical University were retrospectively analyzed. Drug susceptibility test was used to evaluate the resistance of 6 antibacterial drugs (metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline and furazolidone). Unconditional Logistic regression was used to investigate the risk factors affecting Hp antibiotic resistance. Results: In 396 patients with Hp infection, the resistance rates of metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline and furazolidone were 96.5%, 45.5%, 41.9%, 0.3%, 0.3% and 0, respectively. Multivariate analysis showed that previous regimen containing clarithromycin was a risk factor for clarithromycin resistance (P<0.001), and age > 40 years old was a risk factor for levofloxacin resistance (P< 0.001). Conclusions: The resistance rates of metronidazole, clarithromycin and levofloxacin are relatively high, and regimens containing these antibiotics should be avoided without the support from drug susceptibility results, especially in patients who have accepted clarithromycin‑containing regimen or more than 40 years old. Amoxicillin, tetracycline and furazolidone should be recommended preferentially for Hp treatment empirically.
