Characteristics of Esophageal Motility and Efficacy of Proton Pump Inhibitors in Obese Patients With Gastroesophageal Reflux Disease

Author: Yizhou HUANG ¹ ; Bo WANG ¹ ; Yue YU ¹ ; Yizhou HUANG ² ; Jie LIU ² ; Wei WANG ² ; Bo WANG ² ; Jiashuang TIAN ² ; Chaolan LÜ ² ; Yue YU ²
Author Information

1. Graduate School of Bengbu Medical College
2. Department of Gastroenterology, Anhui Provincial Hospital
Publication Type:Journal Article
Keywords: Esophageal Motility; Gastroesophageal Reflux Disease; High-Resolution Manometry; Obesity; Proton Pump Inhibitors
From: Chinese Journal of Gastroenterology 2022;27(2):70-74
CountryChina
Language:Chinese
Abstract: Background: Obesity is an independent risk factor for gastroesophageal reflux disease (GERD), but the mechanism remains unclear. There are few studies focusing on the effectiveness of standard dose proton pump inhibitor (PPI) in treating obese GERD patients. Aims: To investigate the effect of obesity on esophageal motility and acid reflux in GERD patients and the efficacy of standard dose PPI in treating obese GERD patients. Methods: Patients who were initially diagnosed as GERD and met the inclusion criteria from January 2017 to October 2021 at Anhui Provincial Hospital were included in this study. The results of esophageal high-resolution manometry and 24 h esophageal pH-impedance monitoring before PPI treatment in patients with normal body mass index (BMI) and obesity (BMI≥28.0 kg/m