Risk of Epilepsy in Patients With Celiac Disease: A Meta⁃analysis Based on Cohort Studies
10.3969/j.issn.1008-7125.2022.03.003
- Author:
Qimanguli RUZI
1
;
Ting LI
1
;
Feng GAO
1
Author Information
1. Department of Gastroenterology, The People’s Hospital of Xinjiang Uygur Autonomous Region
- Publication Type:Journal Article
- Keywords:
Celiac Disease;
Epilepsy;
Meta-Analysis
- From:
Chinese Journal of Gastroenterology
2022;27(3):144-149
- CountryChina
- Language:Chinese
-
Abstract:
Background: Celiac disease (CD) may have one or more neurological manifestations, and CD may increase the risk of epilepsy. Aims: To systematically evaluate the relationship between CD and epilepsy. Methods: Studies on relationship between CD and epilepsy were retrieved from PubMed, Embase, Cochrane Library, CNKI and Wanfang Data from the date of database establishment to November 2021. According to inclusion and exclusion criteria, literatures were screened, extracted, and the quality of literature was evaluated. Meta - analysis was performed by using Stata/MP 14.0 software. Results: Six studies involving 181 463 subjects were included. Meta-analysis showed that CD was positively associated with the occurrence of epilepsy (OR=1.71, 95% CI: 1.50-1.94, P<0.000 01). Results of subgroup analysis showed that the risk of epilepsy was significantly increased in child patients with CD than in child patients with non-CD (OR=1.79, 95% CI: 1.49-2.15, P<0.000 01), and the risk of epilepsy was significantly increased in adult patients with CD than in adult patients with non-CD (OR=1.29, 95% CI: 1.06-1.57, P=0.01). Conclusions: Compared with patients with non-CD, patients with CD are associated with an increased risk of epilepsy.
