Mechanism of Bmal1 Involved in Irritable Bowel Syndrome via TPH1-5-HT Signaling Pathway in Enterochromaffin Cells

Author: Weiwei ZENG ¹ ; Yanjun WANG ¹ ; Lu ZOU ¹ ; Yuqin HE ¹ ; Shili XIAO ¹ ; Jing WANG ¹ ; Dan QIAO ¹ ; Rong ZHAO ¹ ; Bin WANG ¹ ; Dongfeng CHEN ¹ ; Min YANG ¹ ; Mei ZHAO ² ; Shuai WANG ³
Author Information

1. Department of Gastroenterology, Daping Hospital, Army Medical Center of PLA, Army Medical University
2. Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences
3. Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine
Publication Type:Journal Article
Keywords: 5-Hydroxytryptamine; Brain and Muscle ARNT-Like Protein 1; Circadian Clocks; Circadian Rhythm; Enterochromaffin Cells; Irritable Bowel Syndrome; Tryptophan Hydroxylase 1
From: Chinese Journal of Gastroenterology 2022;27(6):321-327
CountryChina
Language:Chinese
Abstract: Background: Disrupted circadian rhythms have been associated with the development of irritable bowel syndrome (IBS). In some IBS patients, the symptoms may present with circadian fluctuations. Enterochromaffin cells (EC cells) and tryptophan hydroxylase 1 (TPH1) - 5 - hydroxytryptamine (5 - HT) signaling pathway are currently recognized as the key pathophysiological mechanism of IBS. Aims: To explore whether Bmal1, the core circadian clock gene, is involved in the occurrence of IBS by regulating TPH1-5-HT signaling pathway in EC cells. Methods: Normal Sprague-Dawley (SD) rats and IBS-model SD rats, as well as wild type (WT) and intestine-specific Bmal1 knockout (Bmal1