Current Status and Challenges of Research on Biomarkers of Barrett’s Esophagus in Risk Stratification

Xiao Wang; Yunyun HE; Yong Fang; Jiali Zhang; Guangsu Xiong; Xiao Wang; Yunyun HE; Yong Fang; Jiali Zhang; Xiao Zhang; Li LI; Xiao Zhang; Li LI

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Current Status and Challenges of Research on Biomarkers of Barrett’s Esophagus in Risk Stratification

Author: Xiao WANG ¹ ; Yunyun HE ¹ ; Yong FANG ¹ ; Jiali ZHANG ¹ ; Guangsu XIONG ¹ ; Xiao WANG ² ; Yunyun HE ² ; Yong FANG ² ; Jiali ZHANG ² ; Xiao ZHANG ² ; Li LI ³ ; Xiao ZHANG ³ ; Li LI ⁴
Author Information

1. Department of Gastroenterology, Yueyang Hospital, Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
2. Shanghai University of Traditional Chinese Medicine
3. Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
4. Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: Barrett Esophagus; Biomarkers; Graded Management; Precise Treatment; Risk Stratification
From: Chinese Journal of Gastroenterology 2022;27(7):444-448
CountryChina
Language:Chinese
Abstract: Barrett’s esophagus (BE) is the recognized precancerous lesion and risk factor for esophageal adenocarcinoma (EAC), and has a high miss diagnosis rate and low survival rate when malignantly transformed into EAC, moreover, there are only limited monitoring method and treatment. Therefore, the screening of biomarkers is highly expected, especially the risk stratification biomarkers related to the progression of malignant transformation of BE. Such biomarkers can help to determine early, quickly and accurately the disease process, and guide the stratified management and precise treatment of BE, reduce the malignancy rate and mortality. This article focused on the dynamic evolutionary process of intra‑tumor heterogeneity, and reviewed the current status and challenges of research on BE biomarkers in risk stratification from the genetics, epigenetics and serology perspectives.