Role of Gastrointestinal Muscularis Macrophages in Regulation of Gastrointestinal Motility
10.3969/j.issn.1008-7125.2022.07.007
- Author:
Yan WANG
1
;
Xiangyue GAO
1
;
Lin LIN
1
;
Yurong TANG
1
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital)
- Publication Type:Journal Article
- Keywords:
Enteric Nervous System;
Gastrointestinal Motility;
Interstitial Cells of Cajal;
Muscularis Macrophages;
Smooth Muscle Cells
- From:
Chinese Journal of Gastroenterology
2022;27(7):429-433
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have found a special class of macrophages, muscularis macrophages (MMs), in the gastrointestinal tract, which interacts with enteric neuron (EN), interstitial cells of Cajal (ICC), and smooth muscle cells (SMC) to maintain normal intestinal motility. MMs can undergo phenotypic and other changes under altered intestinal microbiota, inflammation, or stress, and act on EN, ICC, or SMC through multiple mechanisms, ultimately affecting gastrointestinal motility. This article reviewed the mechanism of gastrointestinal MMs regulating gastrointestinal motility and role in gastrointestinal motility disorder diseases.
