Progress of Research on Glucagon-like Peptide-2 in Gastrointestinal Tract
10.3969/j.issn.1008.7125.2022.09.008
- Author:
Xiya WANG
1
;
Bin DENG
1
Author Information
1. Department of Gastroenterology, Affiliated Hospital of Yangzhou University
- Publication Type:Journal Article
- Keywords:
Gastrointestinal Neoplasms;
Glucagon-Like Peptide 2;
Insulin-Like Growth Factor I
- From:
Chinese Journal of Gastroenterology
2022;27(9):563-567
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon⁃like peptide⁃2 (GLP⁃2) is a peptide hormone secreted by L cells in the gut. GLP⁃2 plays an important role in anti⁃inflammation, promoting proliferation and repair, and promoting nutrient absorption through various signaling pathways in the gastrointestinal tract. Long ⁃ acting analogs of GLP ⁃ 2 have been used in the treatment of short bowel syndrome and Crohn’s disease, but using GLP⁃2 also has the risk of promoting tumorigenesis. This article introduces GLP ⁃ 2 and its physiological role in gastrointestinal tract, and expounds the possible mechanism of GLP ⁃ 2 related to tumorigenesis and the tumorigenesis risk of endogenous and exogenous GLP⁃2 therapy.
