Exploring Pathogenic Mechanisms of Non-alcoholic Fatty Liver Disease Based on Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
10.3969/j.issn.1008-7125.2022.12.007
- Author:
Chunyan XUE
1
;
Chenyi RAO
1
;
Ling WU
1
;
Xiaoquan HUANG
1
;
Shiyao CHEN
1
;
Feng LI
1
Author Information
1. Department of Gastroenterology, Zhongshan Hospital, Fudan University
- Publication Type:Journal Article
- Keywords:
Endoplasmic Reticulum Stress;
Mitochondrial Dysfunction;
Non-Alcoholic Fatty Liver Disease;
Oxidative Stress;
Unfolded Protein Response
- From:
Chinese Journal of Gastroenterology
2022;27(12):751-754
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by abnormal accumulation of fat in the hepatocytes. Its prevalence is rising globally and has become the most common cause of chronic liver disease worldwide. The pathogenesis of NAFLD is multifaceted, involving insulin resistance, genetic and epigenetic factors, chronic systemic inflammation, mitochondrial dysfunction, endoplasmic reticulum stress, diet, gut microbiota, and other significant contributors. This article primarily delves into the mechanisms of mitochondrial dysfunction and endoplasmic reticulum stress in the development of NAFLD, aiming to provide new insights and therapeutic strategies for NAFLD.
