Progress of Research on Relationship of Circadian Rhythm Disorder and Gut Microbiota Involved in Neurodegenerative Diseases
10.3969/j.issn.1008-7125.2023.01.008
- Author:
Fan WANG
1
;
Di ZHANG
1
;
Lianghao HU
1
;
Zhaoshen LI
1
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Naval Medical University
- Publication Type:Journal Article
- Keywords:
Circadian Rhythm;
Gut Microbiota;
Neurodegenerative Diseases;
Neurodevelopment
- From:
Chinese Journal of Gastroenterology
2023;28(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
With the increase in global life expectancy, the incidence of neurodegenerative diseases is increasing year by year. Studies have confirmed that patients with different types of neurodegenerative diseases have circadian rhythm disorder and gut microbiota dysregulation. The occurrence of neurodegenerative diseases and circadian rhythm disorder are mutually causal, and in this causal relationship, gut microbiota may play an important role. Gut microbiota affects the communication between gut and brain through "microbiota ⁃ gut ⁃ brain axis", and can affect neural development. Gut microbiota dysregulation can increase the risk of neurodegenerative diseases. At the same time, the diurnal fluctuation of gut microbiota themselves is also regulated by the host biological clock. This article reviewed the progress of research on relationship of circadian rhythm disorder and gut microbiota involved in neurodegenerative diseases.
