Causal Association Between Unsaturated Fatty Acids and Inflammatory Bowel Disease: A Mendelian Randomization Analysis
10.3969/j.issn.1008-7125.2023.01.003
- Author:
Jian LI
1
;
Jianshu GAO
1
;
Keke ZHAO
1
;
Hongliang GAO
1
;
Jianshu GAO
2
;
Keke ZHAO
2
;
Hongliang GAO
2
Author Information
1. The Second Department of Gastroenterology, the First Affiliated Hospital of Xinjiang Medical University
2. Graduate School of Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
Colitis, Ulcerative;
Crohn Disease;
Fatty Acids, Omega⁃6;
Fatty Acids, Unsaturated;
Inflammatory Bowel Disease;
Mendelian Randomization Analysis
- From:
Chinese Journal of Gastroenterology
2023;28(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Background: Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of gastrointestinal tract including ulcerative colitis (UC) and Crohn's disease (CD). It is unclear whether there is a causal association between unsaturated fatty acids and IBD. Aims: A two⁃sample Mendelian randomization analysis was used to explore the causal association between unsaturated fatty acids and IBD. Methods: The data of the genome⁃wide association study (GWAS) of unsaturated fatty acids and IBD were obtained from web⁃based public databases. Two⁃sample Mendelian randomization analysis was performed by using inverse⁃variance weighted analysis, and weight median estimator and MR⁃Egger regression were conducted to validate the association of the causal effect. The causality of unsaturated fatty acids on the risk of IBD was evaluated by OR and 95% CI. Results: No direct causal association was found between ω⁃6 fatty acids and CD, and a direct causal association was found with UC. Inverse⁃variance weighted analysis showed a 16% increase in the risk of UC for each standard deviation increase in ω⁃6 fatty acid gene levels (OR=1.16, 95% CI: 1.00⁃1.36, P=0.04). However, no causal association was found between ω⁃3 fatty acids, monounsaturated fatty acids and IBD. Conclusions: ω⁃6 fatty acids may be only causally associated with UC, and no causal association is found between ω⁃3 fatty acids, monounsaturated fatty acids and IBD.
