Clinical Efficacy of Bifid Triple Viable Capsules for Chemotherapy-induced Diarrhea: A Meta-analysis
10.3969/j.issn.1008-7125.2023.03.003
- Author:
Xiaoliang JIN
1
;
Bin LÜ
1
;
Xiaoliang JIN
2
;
Qiujun ZHOU
2
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University
2. The First Clinical Medical College of Zhejiang Medical University
- Publication Type:Journal Article
- Keywords:
Bifid Triple Viable Capsules;
Chemotherapy-Induced Diarrhea;
Malignant Neoplasms;
Meta-Analysis
- From:
Chinese Journal of Gastroenterology
2023;28(3):140-148
- CountryChina
- Language:Chinese
-
Abstract:
Background: Chemotherapy-induced diarrhea (CID) is a major challenge during chemotherapy, which not only affects the quality of life, but also reduces the effectiveness of chemotherapy. Aims: To evaluate the clinical efficacy of Bifid triple viable capsules in the treatment of CID in malignant tumors by using meta - analysis. Methods: Randomized controlled trials (RCTs) on Bifid triple viable capsules for the treatment of CID were retrieved from CNKI, Wanfang, VIP, China Biology Medicine disc, Chinese Clinical Trial Registry, PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrails databases from the date of database establishment to December 2022. According to the inclusion and exclusion criteria, literatures were screened, extracted, and the quality of literature was evaluated. Meta - analysis was performed by using Stata/MP 14.0 software. Results: A total of 10 RCTs including 790 patients were enrolled. Meta - analysis results showed that efficacy of Bifid triple viable capsules in the treatment of CID was significantly increased than that of controls (OR=2.22, 95% CI: 1.69 - 2.92, P<0.000 1), and serum endotoxin, tumor necrosis factor - α, D - lactic acid, diamine oxidase were significantly decreased in Bifid triple viable capsules group than in controls (P<0.05). Conclusions: The addition of Bifid triple viable capsules adjuvant to the original symptomatic treatment of CID can optimize the treatment efficacy.
