Opposite Expression of HNRNPA2B1 in Cancer and Senescent Cells and Its Regulatory Role in Senescence of Cancer Cells
10.13865/j.cnki.cjbmb.2020.12.1481
- Author:
Jun-Hong CAO
1
;
Qi JIA
1
;
Zhao-Zhao ZHAO
1
;
Hai-Mei WEN
1
;
Jun YAO
1
;
Peng YU
1
;
Hai-Jing MA
1
;
Ting NI
1
;
Gang WEI
1
;
Meng CHEN
2
Author Information
1. Ministry of Education {MOE) Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University
2. Eye Institute, Fudan University, Eye and ENT Hospital
- Publication Type:Journal Article
- Keywords:
cancer;
cellular senescence;
E2F transcription factor 1 (E2F1);
heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1 )
- From:
Chinese Journal of Biochemistry and Molecular Biology
2021;37(1):66-75
- CountryChina
- Language:Chinese
-
Abstract:
Splicing factor Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1 ) is associated with mouse lifespan and human longevity.It also plays a causal role in cancer development.However, whether it participates in cellular senescence, a biological process that contributes to individual aging and inhibits cancer, remains unknown.Here, we report that HNRNPA2B1 showed significantly increased expression in various cancer types while consistently decreased expression in multiple cellular senescence models.Knocking down HNRNPA2B1 in cancer cells leads to a series of senescence- associated phenotvpes.In line with its function as a splicing factor, HNRNPA2B1 downregulation causes alternative splicing changes in over one thousand genes, including those known to have a causal role in senescence.Our results also suggests that the E2F transcription factor 1 (E2F1 ) could regulate the expression of HNRNPA2BI, and E2F1-HNRNPA2B1 may be a new regulatory axis functioning in both cancer and cellular senescence, which might also have potential medical implications for cancer therapies.
