Apelin-17 Attenuates ER Stress-associated Apoptosis of MPP
- Author:
Yun-Lu JIANG
1
;
Dan WANG
1
;
Chun-Mei WANG
1
;
Su-Ying LIU
1
;
Jing CHEN
1
;
Bao-Hua CHENG
1
;
Gen-Quan HUANG
1
;
Jing CHEN
2
Author Information
- Publication Type:Journal Article
- Keywords: Apelin-17; endoplasmic reticulum stress; neuroprotection; Parkinson's disease
- From: Chinese Journal of Biochemistry and Molecular Biology 2021;37(9):1250-1265
- CountryChina
- Language:Chinese
- Abstract: Endoplasmic reticulum stress (ERS) is closely related to the development of Parkinson' s disease (PD). Apelin, an endogenous peptide, has a remarkable neuroprotective effect. However, its protective mechanism is still unclear. In the present study, we investigate the molecular mechanism of Apelin-17 reducing the apoptosis of SH-SY5Y cells induced by 1-methyl-4- phenylpyridine (MPP
