The Adaptational Regulation Mechanism of the Apoptosis in Aged Rats’ Striatum in Response to Regular Aerobic Exercise Based on Carbonylation Proteomics

Shun-Ling YUAN; Mei PENG; Yi XIANG; Qi-Ming YANG; Yong LEI; Wen-Feng LIU; Xia LIU; Chang-Fa TANG; Wen-Feng LIU; Da-Zhong YIN; Da-Zhong YIN

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The Adaptational Regulation Mechanism of the Apoptosis in Aged Rats’ Striatum in Response to Regular Aerobic Exercise Based on Carbonylation Proteomics

Author: Shun-Ling YUAN ¹ ; Mei PENG ¹ ; Yi XIANG ¹ ; Qi-Ming YANG ¹ ; Yong LEI ¹ ; Wen-Feng LIU ¹ ; Xia LIU ¹ ; Chang-Fa TANG ¹ ; Wen-Feng LIU ² ; Da-Zhong YIN ² ; Da-Zhong YIN ³
Author Information

1. Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Hunan Normal University, Department of Human Movement Science, College of Physical Education, Hunan Normal University
2. Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, Department of Aging, College of Life Science, Hunan NormalUniversity
3. Aging Experimental Center, Qingyuan People’ s Hospital Affiliated to Guangzhou Medical University
Publication Type:Journal Article
Keywords: 14-3-3 protein (e); electrospray ionization-quadrupole-time of flight mass spectrometer (ESI-Q-TOF-MS); heterogeneous nuclear ribonucleoproteins A2/ B1(HNRNPA2B1); regular aerobic exercise
From: Chinese Journal of Biochemistry and Molecular Biology 2021;37(11):1489-1501
CountryChina
Language:Chinese
Abstract: This paper investigated the effects of regular aerobic exercise on protein oxidative stress and apoptosis in aging rat striatum, and further analyzed its target proteins and mechanism based on differential carbonylation proteomics. Totally 24 specific pathogen-free (SPF) 23-month-old male Sprague-Dawley (SD) rats were randomly divided into aged sedentary control group (Con-SED, n = 12) and aged regular aerobic exercise runner group (Aero-EXE, n = 12). The medium intensity of regular aerobic exercise model: The intensity of maximum oxygen consumption (VO