Pyruvate Supplementation Can Prevent HIIE-induced Metabolic Acidosis and Increase the Expression of MCT1/MCT4 in Skeletal Muscles of Rats
10.13865/j.cnki.cjbmb.2022.08.1182
- Author:
Yan XIE
1
;
Jun ZHANG
1
;
Jun-Qiang QIU
1
;
Yan-Ping YANG
1
;
Kai-Xuan CHE
1
;
Jun-Qiang QIU
2
Author Information
1. Department of Sports Biochemistry, School of Sports Science, Beijing Sport University
2. Beijing Sports Nutrition Engineering Research Center
- Publication Type:Journal Article
- Keywords:
acid metabolism;
high intensity interval exercise (HIIE);
monocarboxylate transporter 1 (MCT1);
monocarboxylate transporter 4 (MCT4);
pyruvate
- From:
Chinese Journal of Biochemistry and Molecular Biology
2022;38(11):1547-1554
- CountryChina
- Language:Chinese
-
Abstract:
As one of the causes of exercise-induced fatigue, exercise-induced metabolic acidosis has attracted much attention. The effect of pyruvate supplementation on exercise-induced metabolic acidosis is rarely reported, and its mechanism has not been fully elucidated. Monocarboxylate transporters (MCTs) play an important role in the maintenance of the acid-base balance, but it is not clear whether pyruvate can alleviate acidosis by increasing the expression of MCTs. In this study, pyruvate (616 mg/kg/day) was supplemented to rats for one week, and then acute HIIE was performed. The HIIE protocol comprised 13 repeats of a 60 s sprint session at 110% VO
