GABA
10.13865/j.cnki.cjbmb.2022.03.1669
- Author:
Xi CHEN
1
;
Xiao-Xi REN
1
;
Ye-Yun DENG
1
;
Kang-Rui LIU
1
;
Jian-Liang ZHANG
1
Author Information
1. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University
- Publication Type:Journal Article
- Keywords:
anti-inflammation;
GABA;
NF-κB signaling pathway;
Parkinson’ s disease (PD)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2022;38(5):630-637
- CountryChina
- Language:Chinese
-
Abstract:
Activation and inflammation of microglial correlate with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson’ s disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, has recently been shown to play an inhibitory role in the immune system, but the mechanism is unclear. In this study, the results showed that LPS promoted the release of inflammatory factors in a dose-dependent manner compared with the control group (P<0. 01). Meanwhile, cell viability and cytotoxicity assays showed that the released inflammatory factors could induce the decline of SH-SY5Y cell viability. BV2 microglia cells were pretreated with GABA and Muscimol, a GABA
