Research Progress of β-Klotho in Energy Metabolism and Tumor Development
10.13865/j.cnki.cjbmb.2023.01.1493
- Author:
Gai-Xia ZHANG
1
;
Hai-Zhen CHEN
1
;
Jing HUANG
1
Author Information
1. Department of Clinical Laboratory, First Hospital of Jilin University
- Publication Type:Journal Article
- Keywords:
fibroblast growth factor 19(FGF19);
fibroblast growth factor 21 (FGF21);
β-Klotho
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(11):1569-1575
- CountryChina
- Language:Chinese
-
Abstract:
β-Klotho (KLB) is a member of the Klotho protein family, which is mainly distributed in organs and tissues such as the liver, fat, pancreas, and brain. KLB is a single-pass transmembrane protein whose structural characteristics determine that KLB acts as a co-receptor for fibroblast growth factor (FGF) 19/21 targeting the activation of fibroblast growth factor receptor (FGFRs). KLB is involved in the regulation of blood glucose, lipids, body weight, bile acid circulation, and hepatocyte proliferation in the FGF21/19-KLB-FGFRs pathway. This paperwill review the structural characteristics and distribution of KLB, as well as the regulatory mechanism of material energy and its role in tumor formation in the FGF19/21-KLB-FGFRs pathways.
