Analysis of the Factors Affecting the Configuration of the Anti-parallel G-quadruplex Formed by 22-nt Telomere RNA Fragments
10.13865/j.cnki.cjbmb.2023.06.1073
- Author:
Ming-Qing ZHONG
1
;
Xiang-Chun SHEN
1
;
Chao-Da XIAO
1
;
Chao-Da XIAO
2
Author Information
1. State Key Laboratory of Functions and Applications of Medicinal Plants
2. Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University
- Publication Type:Journal Article
- Keywords:
2′ hydroxyl group in ribose sugar;
anti-parallel RNA G-quadruplex;
circular dichroism;
loop sequence methylation;
molecular crowding
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(9):1291-1299
- CountryChina
- Language:Chinese
-
Abstract:
G-quadruplexes with different conformations often exhibit different binding abilities to proteins and play different physiological functions. It is of great significance to analyze the factors affecting the configuration of G-quadruplex to explore its physiological function. Different from DNA, RNA sequences have shown parallel G-quadruplex structures in previous reports. However, we found that the only RNA sequence, the 22-nt telomere RNA fragment (ORN-N, A
