Extracellular Expression and Purification of Spider Neurotoxin Hainantoxin-IV in Escherichia coli

Author: Chang-Jun LIU ¹ ; Jian-Jie WANG ¹ ; Yi KE ¹ ; Zhe-Yang ZHANG ¹ ; Hui-Min LI ¹ ; Qing YAN ¹ ; Er MENG ¹ ; Chang-Jun LIU ² ; Er MENG ² ; Chang-Jun LIU ³
Author Information

1. Department of Bioengineering, School of Life and Health Sciences, Hunan University of Science and Technology
2. Key Laboratory of Genetic Improvement and Multiple Utilization of Economic Crops in Hunan Province, Hunan University of Science and Technology
3. Key Laboratory of Ecological Remediation and Safe Utilization of Heavy Metal-polluted Soils, Hunan University of Science and Technology
Publication Type:Journal Article
Keywords: Escherichia coli; extracellular expression; hainantoxin-IV(HNTX-IV)
From: Chinese Journal of Biochemistry and Molecular Biology 2023;39(8):1191-1199
CountryChina
Language:Chinese
Abstract: The spider neurotoxin hainantoxin-IV(HNTX-IV), which is isolated from the crude venom of the spider Selenocosia hainana, can specifically inhibit the tetrodotoxin-sensitive(TTX-S) sodium channel, and can selectively inhibit Voltage-gated sodium channel(VGSC) Na