Expression of Glial Fibrillary Acidic Protein in Human Retinal Macroglia by Immunogold Labeling.
- Author:
Byung Ro LEE
1
;
Sung Keun PARK
;
Myung Kyoo KO
Author Information
1. Department of Ophthalmology, College of Medicine, Kangbuk Samsung Hospital, Sung Kyun Kwan University.
- Publication Type:Original Article
- Keywords:
Age related macular degeneration;
GFAP;
Immunogold labeling;
Macroglia
- MeSH:
Aging;
Astrocytes;
Ependymoglial Cells;
Glial Fibrillary Acidic Protein*;
Humans*;
Macular Degeneration;
Microscopy, Electron;
Retina;
Retinaldehyde*;
Strikes, Employee
- From:Journal of the Korean Ophthalmological Society
1998;39(12):2988-2994
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There are two types of retinal macroglia: astrocyte and Muller cell. The major component of iintermediate filament in astrocyte is GFAP, recognized as the primary marker of astrocyte. Muller cells do not physiologically express GFAP in normal developing retina. A striking increase in GFAP expression. however, is observed in Muller cells under certain pathological condition. It is also suggested that this kind of changes of Muller cells in human retina is related with aging, and may be an early feature of pathogenesis of Age related macular degeneration. The goal of this study is to investigate the involvement of the human retinal macroglia in normal aging by immunogold labeling for electron. The goal of this study is to investigate the involvement of the human retinal macroglia in normal aging by immunogold labeling for electron microscopy. The sections of aged neurosensory retina showed the evidence of expression of GFAP by Muller cells. The results suggest, therefore, that Muller cells are induced to express GFAP during aging.
