Small-leaf Kuding Extract Decreases Hyperglycemia in Mice by Upregulating Nrf2 / INS Expression at the Protein Level

Ming-juan Chen; Shi-nan Wei; Ahmad Mashaal; Jia YU; Sha Cheng; Heng Luo; Shi-nan Wei; Ahmad Mashaal; Jia YU; Sha Cheng; Heng Luo; Ming-juan Chen; Bo-yin Xie; Yuan-zhong Mao

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Small-leaf Kuding Extract Decreases Hyperglycemia in Mice by Upregulating Nrf2 / INS Expression at the Protein Level

Author: Ming-Juan CHEN ¹ ; Shi-Nan WEI ¹ ; Ahmad MASHAAL ¹ ; Jia YU ¹ ; Sha CHENG ¹ ; Heng LUO ¹ ; Shi-Nan WEI ² ; Ahmad MASHAAL ² ; Jia YU ² ; Sha CHENG ² ; Heng LUO ² ; Ming-Juan CHEN ³ ; Bo-Yin XIE ⁴ ; Yuan-Zhong MAO ⁴
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1. State Key Laboratory for Functions and Applications of Medicinal Plants Guizhou Medical University
2. Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academic of Sciences
3. College of Pharmacy, Guizhou Medical University
4. Guizhou Taihe Modern Ecological Agriculture Technology Limited Liability Company
Publication Type:Journal Article
Keywords: extract; hyperglycemia; insulin (INS); Key words Small-leaf Kuding (SLK); nuclear faction-e2-related factor2 (Nrf2)
From: Chinese Journal of Biochemistry and Molecular Biology 2023;39(8):1168-1179
CountryChina
Language:Chinese
Abstract: In recent years, the prevalence of hyperglycemia has been increasing, and patients’ bodies have been seriously damaged. Compared with conventional Western drugs, natural products have fewer adverse reactions and delay the complications of hyperglycemia. As a valuable natural product resource, Small-leaf Kuding (SLK) contains various beneficial components for the human body. The aim of this study was to study the regulation effect of SLK extract at different doses on blood glucose metabolism in hyperglycemic mice. Lipopolysaccharide and streptozotocin were used to induce hyperglycemia in mice. Extract of SLK were administered intragastrically at low, medium, and high doses (5 g·kg