Association between angiotensin converting enzyme and angiotensinogen gene polymorphisms and pregnancy-induced hypertension in Qinghai
10.16098/j.issn.0529-1356.2020.02.024
- Author:
Ru WANG
1
;
Wen-Ting ZHUANG
1
;
Chang-Xing LI
1
;
Jian-Hua LI
1
;
Xiang-Lin WANG
2
;
Hong-Rong LI
3
;
De-Xia KONG
4
Author Information
1. Department of Human Anatomy, Basic Medicine Science, Medical College of Qinghai University
2. Department of Radiology, Huadu District People’s Hospital
3. Department of Surgical, Gansu Wuwei Tumor Hospital
4. Department of Gynecology, The Second People’s Hospital of Xining City
- Publication Type:Journal Article
- Keywords:
Angiotensin-converting enzyme;
Angiotensinogen;
Gene polymorphism;
Polymerase chain reaction-restriction fragment length polymorphism;
Pregnancy-induced hypertension;
Pregnant woman;
Qinghai
- From:
Acta Anatomica Sinica
2020;51(2):294-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between angiotensin converting enzyme (ACE) and angiotensinogen (AGT) gene expression, gene polymorphism and pregnancy-induced hypertension in Qinghai. Methods A total of 210 pregnant hypertensive patients (HDCP group) and 220 normal pregnant women (CK group) were enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect AGT M235T and ACE I/ D gene polymorphism. Results The proportions of ACE gene DD, ID, and Ⅱ in CK group were 28. 15%, 47. 73%, and 24. 09%, respectively. The HDCP group was 33. 81%, 51. 90%, and 14. 29%, respectively (P < 0. 05). The frequency distribution of ACE I/ D polymorphic alleles I and D was different between HDCP group and CK group(P<0. 05). D allele frequency was higher in HDCP group than in CK group (
