Allopregnanolone protecting cell line SH-SY5Y against 6-hydroxydopamine-induced lesion

Author: Tong-Tong WANG ¹ ; Xin YE ¹ ; Wei BIAN ¹ ; Zhi-Chi CHEN ¹ ; Juan-Juan DU ¹ ; Jun-Nan LI ¹ ; Chen-You SUN ¹ ; Tong-Tong WANG ² ; Tong-Tong WANG ³ ; Xin YE ³ ; Wei BIAN ³ ; Zhi-Chi CHEN ³ ; Jun-Nan LI ³ ; Juan-Juan DU ⁴ ; Chen-You SUN ⁴ ; Wei-Da FU ⁵ ; Meng-Jiao CHEN ⁵
Author Information

1. Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University
2. Department of Nursing, School of Medicine and Pharmaceutical Engineering, Taizhou Vocational and Technical College
3. Institution of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University
4. Department of Histology And Embryology, School of Basic Medical Sciences, Wenzhou Medical University
5. Bachelor of Clinical Medicine and Medical Imaging, The First Clinical Medical College, Wenzhou Medical University
Publication Type:Journal Article
Keywords: Allopregnanolone; Brain-derived neurotrophic factor; Calmodulin-dependent kinase II; Dopaminergic neuron; Western blotting; γ-Aminobutyric acid A receptor
From: Acta Anatomica Sinica 2021;52(1):5-13
CountryChina
Language:Chinese
Abstract: Objective To clarify the protective effect of allopregnanolone (APα) on cell line SH-SY5Y damaged by 6-hydroxydopamine (6-OHDA) and its possible molecular mechanism. Methods 6-OHDA, APα, γ-aminobutyric acid A receptor (GABAAR) antagonist, voltage-gated L-type Ca2