Role and mechanism of stabilizing microtubules of endothelial cells and pericytes in improving the microvasculature dysfunction after spinal cord injury
10.16098/j.issn.0529-1356.2021.01.003
- Author:
Yang-Yang DUAN
1
;
Ya-Qun ZHANG
1
;
Yong CHAI
1
;
Lu-Ping ZHANG
1
;
Dong-Mei ZHAO
1
;
Cheng YANG
1
Author Information
1. Department of Anatomy, Binzhou Medical University of Basic Medical Sciences
- Publication Type:Journal Article
- Keywords:
Endothelial cell;
Immunofluorescence;
Microcirculation regeneration;
Microtubule;
Pericyte;
Rat;
Spinal cord injury
- From:
Acta Anatomica Sinica
2021;52(1):21-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role and mechanism of stabilizing microtubules of endothelial cells and pericytes for ameliorating the dysfunction of microvasculature after spinal cord injury(SCI). Methods The endothelial cells and pericytes from rat brain microvascular tissue (microvessel) were separated and subjected to glucose oxygen deprivation (OGD). The cell viability was detected by CCK-8 and the expression of α-tubulin was detected by immunofluorescence and Western blotting. Rats (n = 36) were subjected to dorsal spinal cord transection at T
