Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors
10.16098/j.issn.0529-1356.2021.03.020
- Author:
Ru WANG
1
;
Wen-Ting ZHUANG
1
;
Chang-Xing LI
1
;
Jian-Hua LI
1
;
Xiang-Lin WANG
2
;
Hong-Rong LI
3
;
De-Xia KONG
4
Author Information
1. Department of Human Anatomy, Basic Medicine Science, Medical College of Qinghai University
2. Department of Radiology, Huadu District People's Hospital
3. Department of Surgical, Gansu Wuwei Tumor Hospital
4. Department of Gynecology, The Second People' s Hospital of Xining City
- Publication Type:Journal Article
- Keywords:
Angiotensin-Converting enzyme;
Angiotensinogen;
Enzyme linked immunosorbent assay;
Human;
Pregnancy-induced hypertension;
Risk factor
- From:
Acta Anatomica Sinica
2021;52(3):460-464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum angiotensin converting enzyme (ACE) and angiotensinogen (AGT) and gestational hypertension syndrome (HDCP) and the risk factors of HDCP. Methods A total of 135 pregnant hypertensive patients (HDCP group) and 100 normal pregnant women as control check (CK) group were selected. Serum ACE and AGT levels were measured by ELISA, and correlation analysis was performed. The age and gestational age of the two groups, pre-pregnancy body mass index (BMI), parity, number of births, family history of hypertension, family history, education, and other general information, single factor analysis of risk factors for maternal HDCP, single factor regression analysis Statistically significant factors were all used for multivariate logistic regression analysis. Results The serum ACE level in the HDCP group (90.49±47.65) μg/L was significantly higher than that in the CK group (58.72±27.58) μg/L, P<0.05, the difference was statistically significant. The serum AGT level in the HDCP group was (64.57±19.71) μg/L was higher than CK group (58.22±18.64) μg/L, P>0.05, the difference was not statistically significant; single factor analysis showed; age, BMI, hypertension, family history of diabetes, ACE level was maternal (P<0.05), while gestational age, parity, number of births, and education were no significant differences in risk factors for HDCP (P>0.05). Multivariate analysis showed: age, BMI, history of hypertension and ACE. It was a risk factor for pregnancy-induced hypertension. Conclusion ACE levels are associated with HDCP. AGT levels are not associated with HDCP. Patients with a high age, high BMI, and hypertension history have an increased risk of gestational hypertension syndrome.
