Gray matter abnormalities in obsessive-compulsive disorder by voxel-based morphometry research
10.16098/j.issn.0529-1356.2021.05.004
- Author:
Ruo-Chuan LI
1
;
Jie TANG
2
;
Ling-Zhong FAN
2
;
Yong-Feng YANG
3
;
Hai-Dong ZHANG
4
Author Information
1. School of Basic Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences)
2. Institute of Automation, Chinese Academuy of Sciences
3. He'nan Key Laboratory of Biological Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University
4. School of Clinical Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences)
- Publication Type:Journal Article
- Keywords:
Gray matter volume;
Human;
Magnetic resonance imaging;
Obsessive-compulsive disorder;
Voxel-based morphometry
- From:
Acta Anatomica Sinica
2021;52(5):692-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormalities of gray matter volume in obsessive-compulsive disorder (OCD) patients relative to controls using the method of voxel-based morphometry (VBM), and to analyze the extent of change relative to clinical symptom. Methods Using VBM to compare the MRI images of 31 adult OCD patients with 31 healthy controls. Correlation analyses were conducted between the structural abnormalities of gray matter volume in each brain area among patients relative to their clinical scores. Results Compared with the healthy controls, the OCD patients showed reductions of gray matter volume in left putamen, insula, premotor area, superior parietal and right angular gyrus (P<0.01, Alphasim corrected). The gray matter volumes of left putamen and insular in the OCD patients showed a negative correlation with the Beck anxiety inventory (BAI) scores. Conclusion The changes in gray matter volumes of left putamen, insula, premotor area, superior parietal lobule and right angular gyrus may be related to the pathogenesis of OCD. The declines of left putamen and insula are related to the abnormal anxiety in the OCD patients.
