Dihydromyricetin down-regulating the expression of nod-like receptor protein-3 in the brain tissue of ischemic stroke in rats
10.16098/j.issn.0529-1356.2022.02.001
- Author:
Hui-Ru DING
1
;
Xin-Wei DENG
1
;
Huai-Cun LIU
1
;
Quan-Cheng CHENG
1
;
Xuan FANG
1
;
Chun-Hua CHEN
1
;
Wei-Guang ZHANG
1
;
Guo-Liang ZHANG
2
Author Information
1. Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University
2. Department of Neurobiology, Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Dihydromyricetin;
Inflammasome;
Ischemic stroke;
Longa score;
Middle cerebral artery occlusion;
Nod-like receptor protein-3;
Rat;
TTC staining
- From:
Acta Anatomica Sinica
2022;53(2):137-143
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective To investigate the role of dihydromyricetin (DHM) in the treatment of ischemic stroke in rats, and to explore the effect of DHM on the expression of inflammasome. Methods The middle cerebral artery occlusion (MCAO) model was induced by endovascular suture method. The therapeutic effect and mechanism of DHM were investigated by Longa score, TTC staining, Nissl staining, immunohistochemical staining and Western bloting. Results After DHM treatment, the motor capacity of MCAO rats was significantly improved, the infarct volume was significantly reduced, the brain structure and neuron morphology were improved, and the expressions of nod-like receptor protein-3 (NLRP3) and interleukin-1(IL-1) decreased significantly. Conclusion DHM can down-regulate the expression of NLRP3 and thus reduces the cerebral infarction volume and improves neurobehavioral performance in MCAO rats.
