Advances in morphological and functional studies on the paraventricular thalamic nucleus
10.16098/j.issn.0529-1356.2022.03.020
- Author:
Jia-Ni LI
1
;
Hui LI
1
;
Yu-Lin DONG
1
;
Yun-Qing LI
1
Author Information
1. Department ofAnatomy, Histology and Embryology & K. K. Leung Brain Research Centre, The Air Force Military Medical University
- Publication Type:Journal Article
- Keywords:
Afferent connection;
Efferent connection;
Neuron subclassification;
Paraventricular thalamic nucleus;
Vesicular glutamate transporter-2
- From:
Acta Anatomica Sinica
2022;53(3):402-406
- CountryChina
- Language:Chinese
-
Abstract:
Paraventricular thalamic nucleus (PVT) is an essential component of the midline thalamus, which has been regarded as a transmit relay nucleus and an integrated center in multiple behaviors including wakefulness, food intake, addiction, reward and fear memory. PVT is predominantly populated with glutaminergic excitatory neurons expressing vesicular glutamate transporter-2 (VGluT2) but without GABAergic inhibitory neurons. Therefore, based on the paradox of its multiplexed roles in different behaviors and its comparatively simplex excitatory nature, more specific subclassification of excitatory PVT neurons is required in studies in this field. In the present review, morphological and electrophysiological characteristics, efferent and afferent connections, and morphological and functional distinctions in anterior subregion and posterior subregion of PVT are summarized. In addition, neural connections and neurochemical properties are used as subclassification criteria in PVT neurons. This review might explain the integrated role of PVT in different behaviors, which would be helpful for further studies on the PVT.
