Risk Factors of Postoperative Pneumonia after Lung Cancer Surgery.
10.3346/jkms.2011.26.8.979
- Author:
Ji Yeon LEE
1
;
Sang Man JIN
;
Chang Hoon LEE
;
Byoung Jun LEE
;
Chang Hyun KANG
;
Jae Joon YIM
;
Young Tae KIM
;
Seok Chul YANG
;
Chul Gyu YOO
;
Sung Koo HAN
;
Joo Hyun KIM
;
Young Soo SHIM
;
Young Whan KIM
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea. ywkim@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Complications;
Lung Neoplasms;
Pneumonia;
Risk Factors;
Surgery
- MeSH:
Adult;
Age Factors;
Aged;
Aged, 80 and over;
C-Reactive Protein/analysis;
Carbon Monoxide/metabolism;
Erythrocyte Transfusion;
Female;
Forced Expiratory Volume;
Hospital Mortality;
Humans;
Incidence;
Logistic Models;
Lung Neoplasms/pathology/*surgery;
Male;
Middle Aged;
Neoplasm Staging;
Odds Ratio;
Pneumonia/epidemiology/*etiology/mortality;
*Postoperative Complications;
Retrospective Studies;
Risk Factors;
Vital Capacity
- From:Journal of Korean Medical Science
2011;26(8):979-984
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate risk factors of postoperative pneumonia (POP) after lung cancer surgery. The 417 lung cancer patients who underwent surgical resection in a tertiary referral hospital were included. Clinical, radiological and laboratory data were reviewed retrospectively. Male and female ratio was 267:150 (median age, 65 yr). The incidence of POP was 6.2% (26 of 417) and in-hospital mortality was 27% among those patients. By univariate analysis, age > or = 70 yr (P < 0.001), male sex (P = 0.002), ever-smoker (P < 0.001), anesthesia time > or = 4.2 hr (P = 0.043), intraoperative red blood cells (RBC) transfusion (P = 0.004), presence of postoperative complications other than pneumonia (P = 0.020), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) < 70% (P = 0.002), diffusing capacity of the lung for carbon monoxide < 80% predicted (P = 0.015) and preoperative levels of serum C-reactive protein > or = 0.15 mg/dL (P = 0.001) were related with risk of POP. Multivariate analysis showed that age > or = 70 yr (OR = 3.563, P = 0.014), intraoperative RBC transfusion (OR = 4.669, P = 0.033), the presence of postoperative complications other than pneumonia (OR = 3.032, P = 0.046), and FEV1/FVC < 70% (OR = 3.898, P = 0.011) were independent risk factors of POP. In conclusion, patients with advanced age, intraoperative RBC transfusion, postoperative complications other than pneumonia and a decreased FEV1/FVC ratio have a higher risk for pneumonia after lung cancer surgery.
