Roscovitine rescuing neuronal loss and neuroinflammation in brain regions associated with Parkinson’s disease mice

Author: Ye LIU ¹ ; Ya-Nan CHU ¹ ; Cen-Lu XU ¹ ; Jia-Cheng HE ¹ ; Bing-Yin SU ¹ ; Hao-Ran TAI ¹ ; Ya-Nan CHU ² ; Bing-Yin SU ² ; Hao-Ran TAI ²
Author Information

1. Sichuan Provincial Key Laboratory of Development and Regeneration, Chengdu Medical College
2. Department of Histology and Embryology, Chengdu Medical College
Publication Type:Journal Article
Keywords: 2; 3; 6-tetrahydropyridine; cyclin-dependent kinase 5; Roscovitine; Immunohisochemistry; Mouse; Parkinson’ s disease; 1-Methyl-4-phenyl-1
From: Acta Anatomica Sinica 2023;54(6):635-643
CountryChina
Language:Chinese
Abstract: [Abstract] Objective To investigate the effect and possible mechanism of cell cycle-dependent kinase (Cdk)5 inhibitor Roscovitine on 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced pathological changes in brain regions associated with Parkinson’ s disease (PD) model mice. Methods The effect of Roscovitine on the relative expression levels of P25 and Cdk5 proteins was detected by Western blotting in MPP